ClarityPE-22-28
Spadin analog. Mood and cognition.
About
What it is
PE-22-28 is derived from sortilin propeptide and acts on TREK-1 potassium channels — the same target involved in antidepressant response. It supports mood, reduces anxiety, and enhances cognitive function without typical SSRI side effects.
How it works
PE-22-28 blocks TREK-1 potassium channels, which are involved in mood regulation and are a target for antidepressant therapy. By inhibiting TREK-1, PE-22-28 increases neuronal excitability in mood-relevant circuits, producing anxiolytic and antidepressant-like effects.
Benefits
Who it's for
What to expect
Week 1
Mood and anxiety effects may be felt quickly.
Week 2–3
Cognitive clarity improves alongside mood stabilization.
Week 4–8
Sustained mood and cognitive benefits.
Safety & tolerability
PE-22-28 acts on a well-characterized ion channel target. Unlike traditional SSRIs, it doesn't affect serotonin reuptake and avoids those side effects. Our care team evaluates your mental health history and monitors your response throughout.
How we compound
Single-source API
Every peptide is sourced from one vetted pharmaceutical-grade supplier — no blending from multiple sources.
Third-party tested
Independent labs verify purity, potency, sterility, and endotoxin levels before any batch is released.
Care team reviewed
A real person reviews your profile, your protocol, and your progress. Not an algorithm.
Cognitive & Nootropic
ClarityPE-22-28
Every protocol is reviewed by our care team before it ships. Questions? Learn more
$139/mo
