The Semaglutide+ Stack
Weight loss with metabolic support.
$378/mo
$319/mo
Save $59/mo vs. buying individually
2 protocols included
How This Stack Works
Semaglutide binds to GLP-1 receptors in the hypothalamus, reducing hunger signals, and in the gut, slowing gastric emptying for longer satiety. It also improves pancreatic beta-cell function and insulin sensitivity. MOTS-C is a mitochondrial-derived peptide that activates AMPK (AMP-activated protein kinase), enhancing glucose uptake in skeletal muscle, increasing fatty acid oxidation, and stimulating mitochondrial biogenesis. Together: less intake, better metabolism.
Why This Combination
Semaglutide is the most studied GLP-1 receptor agonist for weight loss — the molecule behind Ozempic and Wegovy. It reduces appetite, slows gastric emptying, and improves insulin sensitivity. But weight loss alone doesn't fix underlying metabolic dysfunction. MOTS-C addresses the cellular layer: it activates AMPK signaling in mitochondria, improving how every cell in your body converts food into usable energy. This means the weight you lose is more likely to stay off because your metabolism is actually working better — not just consuming less. The combination addresses both the behavioral side (appetite) and the biological side (metabolism) of sustainable weight management.
Ideal For
Moderate weight loss goals (10-30 lbs)
Metabolic health improvement alongside weight management
Anyone who wants GLP-1 therapy plus metabolic optimization
Preference for semaglutide over tirzepatide
What to Expect
Week 1–2
Appetite
Semaglutide begins reducing appetite. Food noise decreases. MOTS-C metabolic effects begin building.
Week 3–4
Early Loss
Weight loss begins — typically 2-4 lbs. Energy levels may improve from MOTS-C metabolic enhancement.
Week 6–8
Momentum
Consistent weight loss. Improved fasting glucose and metabolic markers. Body composition begins shifting.
Week 12+
Sustained
Steady weight loss and metabolic improvement. MOTS-C supports maintenance of metabolic rate during caloric deficit.
Ready to start?
The Semaglutide+ Stack — $319/mo. Save $59 vs. buying separately. Care team reviewed. Ships free.
HSA/FSA eligible · Cancel anytime · Ships in 3-5 days