Protocols/Calma
Skin & Anti-Aging

CalmaKPV

The anti-inflammatory peptide for skin that won't calm down.

$119/month
HSA/FSA eligible Ships free Cancel anytime
KPV

About

What it is

KPV is a naturally occurring anti-inflammatory peptide. It modulates the immune response at the skin level, making it useful for inflammatory skin conditions and gut-skin axis support.

How it works

KPV is a tripeptide derived from alpha-MSH that modulates the NF-κB inflammatory pathway. It reduces pro-inflammatory cytokine production at the cellular level, calming overactive immune responses in the skin and gut.

Benefits

Reduces skin inflammation
Supports gut-skin axis health
Modulates immune response
Calms reactive and sensitive skin

Who it's for

Inflammatory skin conditions
Rosacea and eczema support
Gut-related skin issues
Chronic skin sensitivity

What to expect

Week 1–2

Anti-inflammatory signaling begins. Acute flare-ups may calm.

Week 3–4

Sustained reduction in skin reactivity and sensitivity.

Week 6–8

Gut-skin axis benefits may become apparent. Overall inflammation decreases.

Safety & tolerability

KPV is derived from a naturally occurring hormone fragment. It modulates inflammation without broad immunosuppression — a targeted mechanism with a narrow side-effect window. Our formulations use single-source API, batch-tested for purity before compounding. Your care team evaluates your profile to ensure it's appropriate for you.

How we compound

Single-source API

Every peptide is sourced from one vetted pharmaceutical-grade supplier — no blending from multiple sources.

Third-party tested

Independent labs verify purity, potency, sterility, and endotoxin levels before any batch is released.

Care team reviewed

A real person reviews your profile, your protocol, and your progress. Not an algorithm.

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$119/mo